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Pharmaceutical cases require medical experts who can testify not only about causation (that the drug caused the injury) but also about foreseeability (that the manufacturer should have known about the risk)
Conclusions This study represents the largest cohort to date showing that GLP-1 RAs use in KTRs with T2DM is associated with reduced risks of mortality, as well as adverse cardiovascular and kidney outcomes, compared to nonuse
The cognitive and motivational deficits associated with depression, along with feelings of hopelessness, and decreased interest in health management, may contribute to poor adherence to antidiabetic treatment
The dose-dependent nature of semaglutide-associated nodules, documented in the first published case report, suggests that dose reduction may resolve the problem when nodules occur repeatedly
No human clinical trials exist
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